Combined Detection Reagent Of Troponin I,Myoglobin And Creatine
Kinase Isoenzyme Clinical Significance In Emergency
CTnI/MYO/CK-MB Overview
Myoglobin I/myoglobin/creatine kinase isoenzyme (cTnI/Myo/CK-MB)
contains the following three markers: significance in the early
diagnosis of acute cardiomyopathy such as AMI.
American Institute of Clinical Biochemistry (NACB) clinical
guidelines
All patients suspected of having ACS should be examined for markers
of myocardial necrosis.
Troponin is the main diagnostic index of myocardial infarction
Myoglobin binding to specific markers of myocardial necrosis (such
as cTnI/CK-MB) may help to rule out or diagnose myocardial
infarction more quickly.
| | MYO | CK-MB | cTnI |
| molecular weight | 17.8KD | 86KD | 22.5KD |
| Rise time | 1-2h | 4-6h | 3-6h |
| Peak time | 6-9h | 24h | 12-16h |
| recovery time | 18-30h | 2-3d | 4-10d |
| Clinical value | 1. The most important AMI indicator was excluded early 2. The highest evaluation index of AMI recurrence diagnosis and
reperfusion treatment effect | 1. Estimate infarct size or reinfarct 2. MI's most valuable non-ST segment height markers | 1. Preferred marker for AMI diagnosis 2. Judgment of infarction size and risk stratification |
cTnI/MYO/CK-MB Performance Index
| Detection range | sample size | Sample type | Test time |
| cTnI | MYO | CK-MB | 60μl | Whole blood / serum / plasma | 15min |
| 0.1~50ng/mL | 10~200ng/mL | 0.8~100ng/mL |
CTnI/MYO/CK-MB Clinical Significance
- It is helpful for early diagnosis and risk stratification of acute
coronary heart disease.
- The site of myocardial ischemia injury was determined
- Differential diagnosis of multiple causes of chest pain
- Monitoring of multiple causes of myocardial injury
- Evaluation of the clinical efficacy of a specific agent.
| Possibility of outcome | |
| cTnI | CK-MB | MYO | Clinical possibility |
+ | + | + | Myocardial infarction/myocardial injury is basically diagnosable
with a duration of 12-24 hours. |
| + | + | - | The basic diagnosis was myocardial infarction/myocardial injury,
and the detection time was more than 1 day, which exceeded the
detection window time of Myo |
| + | - | - | Myocardial infarction/myocardial injury can occur within 2-3 days,
and it is best to return to the doctor a few hours later. |
| + | - | + | In patients with myocardial infarction/injury, symptoms may take
longer than 3 days to develop and the patient may experience
reinjury or infarction enlargement. |
| - | + | + | For early myocardial infarction/myocardial injury/muscle injury,
cTnI review is recommended within 4-8 hours. |
- | - | + | 1. For early myocardial infarction/myocardial injury, cTnI review
is recommended within 4-8 hours. |
| 2. It can also be caused by other impairments, such as creative
work, skeletal muscle damage, and liver and kidney disease. |
| - | + | - | 1. For mild myocardial injury, cTnI is recommended to be reexamined
within 4-8 hours. |
| 2. It may be non-myocardial injury, and the detection time exceeds
the Myo window time. |
- | - | - | Myocardial infarction or myocardial injury was basically ruled out.
If in doubt, it is best to check every 2 to 4 hours. |
Application Department
Outpatient, emergency, physical examination center, cardiovascular,
ICU, chest pain center and other departments
CTnI/MYO/CK-MB Clinical Comparison
Company profile
Zhongxiu Science And Technology Co.,Ltd., is a high-tech enterprise
engaged in the research and development, production and operation
of in vitro diagnostic products. The in vitro diagnostic products
developed by the company cover POCT series, microbial series,
biochemical series and immune series reagents and supporting
instruments.
The company has always adhered to the core concept of "fast and
accurate, living up to life", committed to providing society with
excellent products and services, and contributing to the cause of
human health.
