Organic Food Grade Immature Sweet Oranges Extract Diosmin Powder
CAS 520-27-4
Detailed Product Description:
Diosmin is manufactured from citrus fruit peels as a phlebotonic
non-prescription dietary supplement used to aid treatment of
hemorrhoids or chronic venous diseases, mainly of the legs.Diomin
was first isolated from the Scrophularia nodosa in 1925 and was
first used as a therapeutic drug in 1962.
Product name | Diosmin |
CAS NO. | 520-27-4 |
Raw material | Hesperidine |
Formula | C28H32O15 |
MOL WT | 609 |
Test method | HPLC |
Place of origin | SiChuan,China(Mainland) |
Storage | Dry place |
Specification:
DETERMINATIONS | SPECIFICATIONS |
Appearance | Grayish-yellow or light yellow hygroscopic powder. |
Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide,
practically insoluble in ethanol(96 per cent). It dissolves in
dilute solutions of alkali hydroxides. |
Identification (2.2.24 & 2.2.29Ph Eur.1611) | A. Infrared absorption spectrophotometry Camparison:diosmin CRS |
| B. The principal peak in the chromatogram obtained with the test
solution is similar in retention time and size to the principal
peak in the chromatogram obtained with reference solution (a) |
Iodine(2.2.36&2.5.10Ph Eur.1611) | ≤0.1% |
Related substances (HPLC) (2.2.29Ph Eur.1611) | Impurity A (Acetoisovanillone) ≤0.5% |
Impurity B (Hesperidin) ≤ 4.0% |
Impurity C ( Isorhoifolin) ≤3.0% |
Impurity D (6-Iododiosmin) ≤0.6% |
Impurity E (Linarin) ≤3.0% |
Impurity F (Diosmetin) ≤2.0% |
Any unspecified impurity ≤0.4% |
Total of impurities ≤8.5% |
Heavy metals (2.4.8 Method C Ph Eur.1611) | ≤20ppm |
Hg (AAS) | ≤0.10ppm |
Water (2.5.12Ph Eur.1611) | ≤6.0% |
Sulphated ash (2.4.14Ph Eur.1611) | ≤0.2% |
Assay on anhydrous basis (2.2.29Ph Eur.1611) | 90.0%~102.0% (on anhydrous basis) |
Pyridine (2.4.24Ph Eur.1611) | ≤200ppm |
Particle size (by laser granulometry) | 80%<2 micron |
Microbiological test (CP2010) | Total bacteria count :≤1000cfu/g |
Moulds and yeasts :≤100cfu/g |
Salmonella: Negative |
E.Coli :Negative |
Remarks: In a word, we can produce as per the client`s specific
rquirements like particle size,color,solubility, signal heavy metal
under Eu rules No629/2008, the other contaminants under EC1881/2006
and residual solvent under directive EC32/2009.
Product Function:
1.Diosmin prolongs the vasoconstrictor effect of norepinephrine on
the vein wall, increasing venous tone, and therefore reducing
venous capacitance, distensibility, and stasis.
2.Diosmin increases the venous return and reduces venous
hyperpressure present in patients suffering from CVI.
3.Diosmin improves lymphatic drainage by increasing the frequency
and intensity of lymphatic contractions, and by increasing the
total number of functional lymphatic capillaries.
4.Diosmin with hesperidine decreases the diameter of lymphatic
capillaries and the intralymphatic pressure.
5.At the microcirculation level, diosmin reduces capillary
hyperpermeability and increases capillary resistance by protecting
the microcirculation from damaging processes.
6.Diosmin reduces the expression of endothelial adhesion
molecules,and inhibits the adhesion, migration, and activation of
leukocytes at the capillary level.Diosmin leads to a reduction in
the release of inflammatory mediators, principally oxygen free
radicals and prostaglandins.
Application :
1. Diosmin is used to treat chronic venous insufficiency,
hemorrhoids, joint edema, venous ulcer of lower extremity,
premenstrual syndrome, microangiopathy in diabetic patients and
upper extremity lymphedema secondary to traditional lung cancer
treatment.
2. clinical application of compound preparation of diozin and
hesperidin.
Company Profile:
Sichuan YuanHongFu Technology co., Limited(YHF) is specialized in
herbs` harvesting, the development & manufacturing of botanical
extracts and their derivatives, is dedicated to the extraction
& purification & innovations of Natural Citrus and Sophorae
Japonica L, as well as the structural modification of these natural
ingredients(Derivatives) that service the pharmaceutical,
nutraceutical, cosmetic and flovor industrial.
Our Advantage:
1. The factory have passed the ISO9001, Kosher, HALAL,FDA,Organic
and Chinese Health Food GMP;
2. We inspect the manufacture process strictly and the quality can
be controlled
3. We supply high quality products, reasonable price, prompt
delivery
4. Our best quality extract with natural and pure. No additives,
organically grown;
We all employee adhering to the business philosophy of "quality
first, forging ahead", we have established long-term and stable
cooperative relationships with many enterprises in domestic and
overseas markets. With superior products and consummate services,
all of our staff members sincerely welcome friends to visit us for
negotiation and cooperation to create a better tomorrow.