Cystatin C (Immunofluorescence Chromatography) (CysC) Clinical
Comparison In ICU
CysC overview
Cysteinase proteinase inhibitor (CPI) was named cystatin C.
Circulation of Cystatin C can only be removed by glomerular
filtration (an endogenous marker that reflects changes in the
glomerular filtration rate) and reabsorbed by the urethral duct
near the stomach curve, but is then completely metabolized and
broken down. It's not reabsorbed, it doesn't go back into the
bloodstream. Therefore, the concentration of cysteine C in blood is
determined by the glomerular filtration rate and is an ideal
endogenous marker to reflect the change of glomerular filtration
rate independent of external factors such as gender, age and diet.
CysC performance index
| Detection range | sample size | Sample type | Test time |
| 0.2~8mg/L | 10μl | Whole blood / serum / plasma | 15min |
Clinical significance of CysC
- It is the ideal endogenous marker of GFR response
- Renal function assessment in high-risk groups for AKI
- Detection of renal function during chronic disease management
Sensitivity comparison of cystatin C and serum creatinine in the
evaluation of GFR
| | Cystatin C | Cystatin C |
| creatinine | |
| GFR(mL/min/1.73m2) | >89 | 60-89 | 30-59 | 15-29 | <15 |
| CKD stage | 1 | 2 | 3 | 4 | 5 |
| | GFR normal / elevated kidney damage | Mild renal insufficiency | moderate renal insufficiency | Severe renal insufficiency | End stage renal disease (ESRD) |
Application Department
Internal medicine, pediatrics, orthopedics, cardiology, emergency,
ICU, Nephrology, oncology, surgery, etc
Clinical comparison of CysC
Company profile
Zhongxiu Science And Technology Co.,Ltd., is a high-tech enterprise
engaged in the research and development, production and operation
of in vitro diagnostic products. The in vitro diagnostic products
developed by the company cover POCT series, microbial series,
biochemical series and immune series reagents and supporting
instruments.
The company has always adhered to the core concept of "fast and
accurate, living up to life", committed to providing society with
excellent products and services, and contributing to the cause of
human health.
