Hydroxyapatite is a kind of bioactive bioceramic material. Its
composition is very similar to the inorganic components of human
teeth. It has good affinity with teeth. Therefore, in the process
of brushing teeth, hydroxyapatite is easy to adsorb on the surface
of teeth defects, and closely combined with teeth to achieve the
role of repairing and strengthening teeth. Dental caries is the
main form of tooth damage, Dextran is a polysaccharide polymer
produced by Streptococcus mutans metabolizing glucose. It can be
used by bacteria to produce acid, which can demineralize enamel and
cause dental caries. Hydroxyapatite can adsorb Streptococcus
mutans, It can prevent dental caries. Acicular hydroxyapatite below
50 nm has better remineralization hardness, demineralization
coverage rate and adsorption capacity (adsorption capacity of
Streptococcus mutans) for demineralized teeth. Therefore, the
addition of acicular hydroxyapatite below 50 nm in toothpaste will
have better effect of repairing teeth and preventing caries
The antibacterial effect and remineralization effect on artificial
caries were studied by antibacterial test and remineralization test
respectively. The results showed that nano hydroxyapatite (nano
HAP) had a very significant inhibitory effect on the growth of
Streptococcus mutans (P ＜ 0.01). After 10 days of remineralization
of artificial caries by toothpaste containing 5% nano hap, The
results showed that the microhardness of enamel was significantly
improved (P ＜ 0.01). The toothpaste containing 5% nano
hydroxyapatite (nano HAP) had caries prevention effect
| Product Name | Nnno hydroxyapatite |
| Particle size | 60nm |
| Purity | 96% |
| Crystal form | Acicular |
| Color | White |
| Packaging and storage | aluminum foil bag:50g/bag; 1kg/bag; |
Hydroxyapatite, also known as hydroxyapatite, basic calcium
phosphate, is the natural mineralization of calcium apatite (Ca5
(PO4) 3 (OH)). But it is often written in the form of (CA10 (PO4) 6
(OH) 2) to highlight that it is composed of two parts: hydroxy and
apatite. OH group can be replaced by fluoride, chloride and
carbonate ion to form fluoroapatite or chloroapatite. Calcium ion
can be replaced by various metal ions through ion exchange reaction
to form corresponding metal ion m apatite (M represents gold ion
replacing calcium ion). Hydroxyapatite (HAP) is the main inorganic
component of vertebrate bones and teeth. The content of HAP in
human enamel is about 96 wt.% (92 vol.%), and that in bone is about
69 wt.%. Hydroxyapatite has excellent biocompatibility and
bioactivity, and can be used as a bone or tooth inducer, which has
good remineralization, desensitization and whitening effect on
teeth in the field of oral health care. The results show that HAP
particles have good biocompatibility and high affinity with enamel.
The mineralized solution can effectively form remineralization
deposit, prevent calcium ion loss, solve enamel demineralization
problem and fundamentally prevent dental caries. The toothpaste
containing HAP material has strong adsorption effect on salivary
protein and dextran, can reduce dental plaque of patients, promote
gingivitis healing, and have good prevention and treatment effect
on caries and periodontal disease.
