TOC-750S Automatic TOC Analyzer Total Organic Carbon TOC Analysis

TOC-750S TOC Analyzer

Product introduction

The TOC-750S Total Organic Carbon Analyzer test the total organic carbon concentration in water samples. It can detect water samples with TOC concentrations ranging from 0.001 mg/L to 100.0 mg/L with high sensitivity, accuracy, and good stability.

The TOC-750S Total Organic Carbon Analyzer is a simple online testing instrument. The main components are installed on the main unit. Before measurement, the instrument needs to be connected to the gas line and the reagents are prepared. The instrument is controlled by a special software installed on the instrument display to perform measurement, calibration, printing and other data processing tasks.

Application

Ø Deionized water samples such as water for injection and purified water

Ø Cleaning validation for the pharmaceutical industry

Ø Environmental water such as tap water and surface water

Ø Chemical water (washing water, cooling water, recycled water, etc.)

Ø Laboratory research

Working principle

The TOC-750S Total Organic Carbon Analyzer utilizes the UV-persulfate oxidation-NDIR detection principle. One sample is fully oxidized by UV and persulfate to produce CO2, while another sample is treated with an acid reagent to decompose inorganic carbon into CO2. The CO2 is then dried and cleaned with a carrier gas before entering a non-dispersive infrared (NDIR) detector for measurement, thereby determining the carbon concentration in the sample.

                                                                       Working principle diagram

 Test modes

Technical parameters

Features

 Complies with the requirements of EP, USP, and the 2020 edition of the Chinese Pharmacopoeia.

 Four detection modes: TC, TIC, TOC, and NPOC, all performed in a single reactor.

 A highly reflective gold-plated gas chamber, a highly concentrated infrared light source, and a highly sensitive infrared detector ensure excellent NDIR performance, enabling sensitive and accurate measurements down to the ppb level.

 A precision electromagnetic metering pump ensures accurate and stable injection volume.

 Dual-pass electronic condensation dehydration technology.

 Real-time visualization of detection curves for enhanced visualization.

 Real-time self-monitoring of temperature, pressure, and flow at multiple locations.

 Customizable curves can be customized to meet the measurement needs of any water sample.

 Optional online module enables online monitoring.

 Optional autosampler allows for unattended operation, saving manpower and time.

Standards

Ø USP <643> Total Organic Carbon (TOC) Method

Ø Chinese Pharmacopoeia 2020 Edition, Part IV, 0682, Determination of Total Organic Carbon in Water for Injection

Ø GMP Appendix: Computerized System Validation

Ø 21 CFR Part 11

Software

The software meets GMP computer system validation requirements:

Electronic Signature

1) Login via unique username and password.

2) Password length requirements enhance security.

3) A manual lock screen function ensures unique and secure operation.

Permission Management

1) Multi-level permission settings.

2) Administrators can grant different permissions to other operators, ensuring that personnel only have permissions commensurate with their job responsibilities.

Data Integrity

1) Audit trail functionality is available and cannot be disabled.

2) All test results are saved and cannot be modified or deleted.

3) All operations are logged (all access records are kept).

4) If a test method is modified, the modified parameters are recorded.

5) Data can be exported and backed up to protect stored data for future use.

Measurement interface:

1) Real-time display of measurement curves for greater clarity

2) Automatic calculation of average values

3) Efficient measurement: a single analysis takes only 3 minutes

Report format:

1) Comprehensive sample test report, fully documenting sample information and measurement data

2) Reports can be printed by year, month, day, or individual sample information

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